EPA Softgels vs RXOmega-3: Which Omega-3 Is Right?

Compare Nordic Naturals EPA and Natural Factors RXOmega-3 Ultra Strength to find the best omega-3 supplement for your needs, with clear trade-offs on potency, cost, and formulation.

Publishing teamXI LANGS Editorial

PublishedOct 28, 2026

Page updatedOct 28, 2026

Reading time3 minutes

EPA Softgels vs RXOmega-3: Which Omega-3 Is Right?

Quick answer

Choose Nordic Naturals EPA if you want a high-EPA formula focused on mood support; choose Natural Factors RXOmega-3 Ultra Strength if you need a potent, all-around omega-3 with added DPA in a convenient enteric softgel.

Potency and convenience: one capsule vs. two

RXOmega-3 Ultra Strength delivers a higher total omega-3 dose per softgel, which means you may need fewer capsules daily. Nordic Naturals EPA provides a targeted 850 mg of EPA plus 200 mg of DHA per serving (two softgels), so you get a higher ratio of EPA to DHA without the extra DPA.

Formulation focus: EPA-driven vs. broad-spectrum

Nordic Naturals EPA is built around EPA, the omega-3 most studied for mood and emotional well-being. RXOmega-3 includes DPA, a less common omega-3 that may support joint and vascular health, making it a broader-spectrum choice.

Digestive comfort: enteric coating matters

RXOmega-3 uses Enteripure® enteric softgels, designed to bypass the stomach and dissolve in the intestine. This can reduce fishy burps and stomach upset for sensitive users. Nordic Naturals EPA does not use enteric coating, so some people may notice mild reflux.

Trade-offs at a glance

Higher total omega-3 dose: RXOmega-3 Ultra Strength packs more omega-3 per capsule, so you take fewer softgels daily. Best if you dislike swallowing many pills.
EPA-focused formula: Nordic Naturals EPA delivers a high EPA-to-DHA ratio, ideal for mood and emotional health. Choose this if EPA is your priority and you don't need DPA.
Enteric coating for comfort: RXOmega-3's enteric softgels reduce fishy burps and stomach upset, while Nordic Naturals EPA lacks this coating. Sensitive stomachs will prefer the enteric option.

Product facts

Nordic Naturals EPA Softgels: Nordic Naturals EPA provides up to 850 mg of EPA per serving, plus 200 mg of DHA, in a fish oil formula that prioritizes EPA for feel-good benefits. If your main goal is mood support, this high-EPA ratio targets that without extra DPA or enteric coating.

Nordic Naturals EPA Softgels
Natural Factors RXOmega-3 Ultra Strength Softgels: Natural Factors RXOmega-3 Ultra Strength is a concentrated fish oil with EPA, DHA, and DPA in Enteripure® enteric softgels, offering a higher-potency option in fewer capsules. The enteric coating can reduce digestive side effects, and the DPA adds joint and vascular support beyond standard EPA/DHA.

Natural Factors RXOmega-3 Ultra Strength Softgels