Quick answer

Choose the Mackie 1604VLZ4 if you need 16 Onyx preamps for maximum inputs; pick the 1642VLZ4 if you want a lower cost and can work with 10 Onyx preamps plus 6 line-only channels.

Preamp count matters more than channel count

Both mixers list 16 input channels, but the 1604VLZ4 equips all 16 with an Onyx mic preamp, while the 1642VLZ4 has 10 Onyx preamps and 6 line-level-only channels. If you need to mic 16 sources simultaneously—drums, multiple vocals, or a full band—the 1604VLZ4 is the straightforward choice. For smaller setups where a few inputs are line-level (keyboards, drum machines, playback), the 1642VLZ4 saves money without sacrificing the core analog mixer quality.

Price difference reflects the preamp count

The 1604VLZ4 lists at $671.99 (catalog comparison $1049.99), while the 1642VLZ4 lists at $495.99 (catalog comparison $799.99). The $176 gap comes entirely from the extra six Onyx preamp channels. For many live or studio applications, that extra cost is justified by the flexibility to handle any input type. If your typical setup rarely uses more than 10 mics, the 1642VLZ4 leaves budget for other gear.

Trade-offs at a glance

  • Preamp count: 1604VLZ4: 16 Onyx preamps. 1642VLZ4: 10 Onyx preamps + 6 line-only channels. Count your mic inputs before deciding.
  • Price: 1604VLZ4: $671.99. 1642VLZ4: $495.99. The 1642VLZ4 saves $176 if you don't need all 16 preamps.
  • Build and bus design: Both use a 4-bus compact analog design with a rugged steel chassis. Build quality is identical; pick based on preamp needs, not durability.

Product facts

Which mixer fits your rig?

Best for

  • Bands or studios that need 16 mic inputs for drums, vocals, and instruments
  • Users who want maximum flexibility without external preamps

Not for

  • Budget-conscious setups that only need 10 or fewer mic inputs
  • Users who can work with line-level sources on the remaining channels